Doses of Ultraviolet Radiation that Modulate Accessory Cell Activity and ICAM-1 Expression Are Ultimately Cytotoxic for Murine Epidermal Langerhans Cells

Effects of ultraviolet radiation on Langerhans cells

Research on penetration of ultraviolet (UV) radiation into human skin shows that about 20% of UVA and 10% of UVB can reach the basal layer of the epidermis. As a consequence, Langerhans cells (LCs), located in suprabasal layers, are subject to the influence of the two types of UV radiation. This phenomenon leads to quantitative and qualitative alterations in LCs, including reduction in their nu...

Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions.

A new langerin(+) DC subset has recently been identified in murine dermis (langerin(+) dDC), but the lineage and functional relationships between these cells and langerin(+) epidermal Langerhans cells (LC) are incompletely characterized. Selective expression of the cell adhesion molecule EpCAM by LC allowed viable LC to be easily distinguished from langerin(+) dDC in skin and lymphoid tissue an...

Radiation Langerhans Cell Maturation by Ultraviolet B Differential Modulation of Human Epidermal

Differential modulation of human epidermal Langerhans cell maturation by ultraviolet B radiation.

UVB irradiation of the skin causes immunosuppression and Ag-specific tolerance in which Langerhans cells (LC) are involved. We tested the effect of UVB on LC that had migrated out of cultured epidermal sheets derived from the skin that was irradiated ex vivo (200, 400, 800, or 1600 J/m2). Two separate subpopulations of LC were distinguished: large-sized LC with high HLA-DR expression, and HLA-D...

The Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity

Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...